Article
Genetics and autoantibodies.
Immunologic research - 1 Jul 2013
Perricone Carlo, Agmon-Levin Nancy, Ceccarelli Fulvia, Valesini Guido, Anaya Juan-Manuel, Shoenfeld Yehuda
Abstract excerpt
Autoimmune diseases (ADs) are chronic conditions initiated by the loss of immunological tolerance to self-antigens. The pathogenic hypothesis comprises a complex interaction between genetic, environmental and hormonal factors that interact with an individual over time generating a dysregulation of the immune system leading to disease development. Several polymorphic genes contribute to the development of ADs....
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