Article
SLAF-seq: an efficient method of large-scale de novo SNP discovery and genotyping using high-throughput sequencing.
PloS one - 1 Jan 2013
Sun Xiaowen, Liu Dongyuan, Zhang Xiaofeng, Li Wenbin, Liu Hui, Hong Weiguo, Jiang Chuanbei, Guan Ning, Ma Chouxian, Zeng Huaping, Xu Chunhua, Song Jun, Huang Long, Wang Chunmei, Shi Junjie, Wang Rui, Zheng Xianhu, Lu Cuiyun, Wang Xiaowu, Zheng Hongkun
Abstract excerpt
Large-scale genotyping plays an important role in genetic association studies. It has provided new opportunities for gene discovery, especially when combined with high-throughput sequencing technologies. Here, we report an efficient solution for large-scale genotyping. We call it specific-locus amplified fragment sequencing (SLAF-seq). SLAF-seq technology has several distinguishing characteristics: i) deep...
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