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Article

Balance between autophagic pathways preserves retinal homeostasis

23 Mar 2013

Abstract excerpt

Aging contributes to the appearance of several retinopathies and is the largest risk factor for aged-related macular degeneration, major cause of blindness in the elderly population. Accumulation of undegraded material as lipofuscin represents a hallmark in many pathologies of the aged eye. Autophagy is a highly conserved intracellular degradative pathway that plays a critical role in the removal of damaged cell...

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PMID: 23521856
DOI: 10.1111/acel.12072

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