Article
High-efficiency transduction of primary human hematopoietic stem cells and erythroid lineage-restricted expression by optimized AAV6 serotype vectors in vitro and in a murine xenograft model in vivo.
PloS one - 1 Jan 2013
Song Liujiang, Li Xiaomiao, Jayandharan Giridhara R, Wang Yuan, Aslanidi George V, Ling Chen, Zhong Li, Gao Guangping, Yoder Mervin C, Ling Changquan, Tan Mengqun, Srivastava Arun
Abstract excerpt
We have observed that of the 10 AAV serotypes, AAV6 is the most efficient in transducing primary human hematopoietic stem cells (HSCs), and that the transduction efficiency can be further increased by specifically mutating single surface-exposed tyrosine (Y) residues on AAV6 capsids. In the prese...
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