Article
Vitellogenin receptor mutation leads to the oogenesis mutant phenotype "scanty vitellin" of the silkworm, Bombyx mori.
The Journal of biological chemistry - 10 May 2013
Lin Ying, Meng Yan, Wang Yan-Xia, Luo Juan, Katsuma Susumu, Yang Cong-Wen, Banno Yutaka, Kusakabe Takahiro, Shimada Toru, Xia Qing-You
Abstract excerpt
BACKGROUND: The vitellogenin receptor (VgR) mediates the uptake of vitellogenin (Vg) from the hemolymph by developing oocytes. RESULTS: VgR with the mutational EGF1 domain can bind ligand proteins but cannot be dissociated under acidic conditions. The mutant is lethal in embryos. CONCLUSION: Bombyx mori VgR (BmVgR) has an important role in egg formation and embryonic development. SIGNIFICANCE: BmVgR is a...
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