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Article

Heme and FLVCR-related transporter families SLC48 and SLC49.

Molecular aspects of medicine - 1 Jan 2000

Khan Anwar A, Quigley John G

Abstract excerpt

Heme is critical for a variety of cellular processes, but excess intracellular heme may result in oxidative stress and membrane injury. Feline leukemia virus subgroup C receptor (FLVCR1), a member of the SLC49 family of four paralogous genes, is a cell surface heme exporter, essential for erythropoiesis and systemic iron homeostasis. Disruption of FLVCR1 function blocks development of erythroid progenitors,...

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Source

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Identifiers

PMID: 23506900
DOI: 10.1016/j.mam.2012.07.013
PMCID: PMC3602793

Genes

FLVCR1
FLVCR2
HRG

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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