Article
Subpopulations of Staphylococcus aureus clonal complex 121 are associated with distinct clinical entities.
PloS one - 1 Jan 2013
Kurt Kevin, Rasigade Jean-Philippe, Laurent Frederic, Goering Richard V, Žemličková Helena, Machova Ivana, Struelens Marc J, Zautner Andreas E, Holtfreter Silva, Bröker Barbara, Ritchie Stephen, Reaksmey Sin, Limmathurotsakul Direk, Peacock Sharon J, Cuny Christiane, Layer Franziska, Witte Wolfgang, Nübel Ulrich
Abstract excerpt
We investigated the population structure of Staphylococcus aureus clonal complex CC121 by mutation discovery at 115 genetic housekeeping loci from each of 154 isolates, sampled on five continents between 1953 and 2009. In addition, we pyro-sequenced the genomes from ten representative isolates. The genome-wide SNPs that were ascertained revealed the evolutionary history of CC121, indicating at least six major...
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