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Article

A novel fibrinogen mutation (γ Thr277Arg) causes hereditary hypofibrinogenemia in a Chinese family.

Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis - 1 Sept 2013

Zhu Liqing, Wang Mingshan, Xie Haixiao, Jin Yanhui, Yang Lihong, Xu Pengfei

Abstract excerpt

Congenital hypofibrinogenemia is a rare disorder caused by heterozygous mutations in one of the three fibrinogen genes--fibrinogen α-chain (FGA), fibrinogen β-chain (FGB) and fibrinogen γ-chain (FGG)--which code for the Aα, Bβ and γ chains, respectively. In this study, we identified a genetic defect in the FGG underlying the hypofibrinogenemia. The proposita had a prolonged blood clotting time (thrombin time...

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Source

Identifiers

PMID: 23492915
DOI: 10.1097/MBC.0b013e32835facdc

Genes

FGG
FGA
FGB

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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