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Article

RNAi-mediated gene suppression in a GCAP1(L151F) cone-rod dystrophy mouse model.

PloS one - 1 Jan 2013

Jiang Li, Li Tansy Z, Boye Shannon E, Hauswirth William W, Frederick Jeanne M, Baehr Wolfgang

Abstract excerpt

Dominant mutations occurring in the high-affinity Ca(2+)-binding sites (EF-hands) of the GUCA1A gene encoding guanylate cyclase-activating protein 1 (GCAP1) cause slowly progressing cone-rod dystrophy (CORD) in a dozen families worldwide. We developed a nonallele-specific adeno-associated virus (AAV)-based RNAi knockdown strategy to rescue the retina degeneration caused by GCAP1 mutations. We generated three...

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Identifiers

PMID: 23472098
DOI: 10.1371/journal.pone.0057676
PMCID: PMC3589431

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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