Article
Impact of antibodies against amyloidogenic transthyretin (ATTR) on phenotypes of patients with familial amyloidotic polyneuropathy (FAP) ATTR Valine30Methionine.
Clinica chimica acta; international journal of clinical chemistry - 18 Apr 2013
Obayashi Konen, Tasaki Masayoshi, Jono Hirofumi, Ueda Mitsuharu, Shinriki Satoru, Misumi Yohei, Yamashita Taro, Oshima Toshinori, Nakamura Teruya, Ikemizu Shinji, Anan Intissar, Suhr Ole, Ando Yukio
Abstract excerpt
BACKGROUND: This study investigated whether a relationship exists between the presence of de novo antibodies and the clinical manifestations of familial amyloidotic polyneuropathy (FAP). METHODS: Serum samples were collected from 25 Japanese and 6 Swedish FAP amyloidogenic transthyretin (ATTR) Valine30Methionine (V30M) patients, 4 asymptomatic Japanese ATTR V30M gene carriers, and 24 Japanese healthy volunteers....
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