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Article

Antibody recognition of amyloidogenic transthyretin variants in serum of patients with familial amyloidotic polyneuropathy.

Journal of molecular medicine (Berlin, Germany) - 1 Jan 2001

Palha J A, Moreira P, Olofsson A, Lundgren E, Saraiva M J

Abstract excerpt

Familial amyloidotic polyneuropathy (FAP) is a late-onset inherited disease characterized by the deposition of amyloid fibrils. FAP is associated with mutations on the transthyretin (TTR) gene. A monoclonal antibody, MAb 39-44, reacting with high molecular weight aggregates of TTR but not with tetrameric TTR has recently been generated and characterized. This antibody recognizes a cryptic epitope that is...

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Topics

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Share to Amyloid Neuropathies, Familial
Share to Antibodies, Monoclonal

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Antibody Specificity

Share to Enzyme-Linked Immunosorbent Assay

Share to Mass Spectrometry

Share to Peptide Fragments

Share to Polymorphism, Single-Stranded Conformational

Share to Prealbumin

Source

Identifiers

PMID: 11434723
DOI: 10.1007/s001090000163

Genes

TTR
FAP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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