Long-lasting effect of perinatal exposure to L-tryptophan on circadian clock of primary cell lines established from male offspring born from mothers fed on dietary protein restriction.

doi:10.1371/journal.pone.0056231

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Long-lasting effect of perinatal exposure to L-tryptophan on circadian clock of primary cell lines established from male offspring born from mothers fed on dietary protein restriction.

PloS one - 1 Jan 2013

Nascimento Elizabeth, Guzman-Quevedo Omar, Delacourt Nellie, da Silva Aragão Raquel, Perez-Garcia Georgina, de Souza Sandra Lopes, Manhães-de-Castro Raul, Bolaños-Jiménez Francisco, Kaeffer Bertrand

Abstract excerpt

BACKGROUND AIMS: Maternal undernutrition programs metabolic adaptations which are ultimately detrimental to adult. L-tryptophan supplementation was given to manipulate the long-term sequelae of early-life programming by undernutrition and explore whether cultured cells retain circadian clock dysregulation. METHODS: Male rat pups from mothers fed on low protein (8%, LP) or control (18%, CP) diet were given, one...

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Long-lasting effect of perinatal exposure to L-tryptophan on circadian clock of primary cell lines established from male offspring born from mothers fed on dietary protein restriction.

Abstract excerpt

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