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Article

Identification and promoter analysis of PERV LTR subtypes in NIH-miniature pig.

Molecules and cells - 1 Feb 2013

Jung Yi-Deun, Ha Hong-Seok, Park Sang-Je, Oh Keon-Bong, Im Gi-Sun, Kim Tae-Hun, Seong Hwan-Hoo, Kim Heui-Soo

Abstract excerpt

Porcine endogenous retroviruses (PERVs) are integrated into the genomes of all pigs. Since some PERVs can also infect human cells, they represent a potential risk for xenotransplantation involving pig cells or organs. The long terminal repeat (LTR) elements of PERVs show promoter activity that can affect human functional genes; therefore, we examined these elements in this study. We detected several expressed...

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Identifiers

PMID: 23456331
DOI: 10.1007/s10059-013-2289-6
PMCID: PMC3887905

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