Article
Zebrafish churchill regulates developmental gene expression and cell migration.
Developmental dynamics : an official publication of the American Association of Anatomists - 1 Jun 2013
Taibi Andrew, Mandavawala Kunal P, Noel Justine, Okoye Ejike V, Milano Carolyn R, Martin Benjamin L, Sirotkin Howard I
Abstract excerpt
BACKGROUND: Regulation of developmental signaling pathways is essential for embryogenesis. The small putative zinc finger protein, Churchill (ChCh) has been implicated in modulation of both TGF-β and FGF signaling. RESULTS: We used zinc finger nuclease (ZFN) mediated gene targeting to disrupt the zebrafish chch locus and generate the first chch mutations. Three induced lesions produce frameshift mutations that...
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