Article
Characterization of Enterococcus faecium with macrolide resistance and reduced susceptibility to quinupristin/dalfopristin in a Japanese hospital: detection of extensive diversity in erm(B)-regulator regions.
Microbial drug resistance (Larchmont, N.Y.) - 1 Aug 2013
Isogai Nayuta, Urushibara Noriko, Kawaguchiya Mitsuyo, Ghosh Souvik, Suzaki Keisuke, Watanabe Naoki, Quiñones Dianelys, Kobayashi Nobumichi
Abstract excerpt
Cross-resistance to macrolide, lincosamide, and streptogramin B (MLSB) antibiotics is mainly mediated by the erm (erythromycin ribosome methylation) genes that encode 23S rRNA methylases in enterococi, and various mechanisms are involved in the streptogramin B resistance. Prevalence of MLSB resistance and its genetic mechanisms were analyzed for a total of 159 strains of Enterococcus faecium isolated from...
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