Article
Silenced expression of NFKBIA in lung adenocarcinoma patients with a never-smoking history.
Acta medica Okayama - 1 Jan 2013
Furukawa Masashi, Soh Junichi, Yamamoto Hiromasa, Ichimura Kouichi, Shien Kazuhiko, Maki Yuho, Muraoka Takayuki, Tanaka Norimitsu, Ueno Tsuyoshi, Asano Hiroaki, Tsukuda Kazunori, Toyooka Shinichi, Miyoshi Shinichiro
Abstract excerpt
Nuclear factor of κ-light polypeptide gene enhancer in B cells inhibitor α (NFKBIA), which is a tumor suppressor gene, was found to be silenced in lung adenocarcinomas. We examined NFKBIA expression, mutations in the EGFR and K-ras genes, and EML4-ALK fusion in 101 resected lung adenocarcinoma samples from never-smokers. NFKBIA expression was evaluated using immunohistochemistry. NFKBIA expression was negative in...
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