Model of haplotype and phenotype in the evolution of a duplicated autoregulatory activator.

Abstract excerpt

Gene duplication is believed to play a major role in the evolution of genomic complexity. The presence of a duplicate frees a gene from the constraint of natural selection, leading to its loss of function or the gain of a novel one. Alternately, a pleiotropic gene might partition its functions among its duplicates, thus preserving both copies. Such arguments invoking duplication for novelty or specialisation are...

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