Article
Parkinsonism is a late, not rare, feature of CADASIL: a study on Italian patients carrying the R1006C mutation.
Stroke - 1 Apr 2013
Ragno Michele, Berbellini Alfonso, Cacchiò Gabriella, Manca Antonio, Di Marzio Fabio, Pianese Luigi, De Rosa Anna, Silvestri Serena, Scarcella Maria, De Michele Giuseppe
Abstract excerpt
BACKGROUND AND PURPOSE: To describe parkinsonism as a clinical manifestation of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy. METHODS: We report 5 patients carrying the R1006C mutation in the exon 19 of NOTCH3 gene. All cases presented late onset, slowly progressive parkinsonism, not responsive to l-dopa. We performed brain MRI and (123)I-FP-CIT SPECT in all and in 3...
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