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Article

Characterization of Ovine Nectin-4, a Novel Peste des Petits Ruminants Virus Receptor

7 Feb 2013

Abstract excerpt

Small ruminants infected with peste des petits ruminants virus exhibit lesions typical of epithelial infection and necrosis. However, the only established host receptor for this virus is the immune cell marker signaling lymphocyte activation molecule (SLAM). We have confirmed that the ovine Nectin-4 protein, when overexpressed in epithelial cells, permits efficient replication of PPRV. Furthermore, this gene was...

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PMID: 23388720
DOI: 10.1128/jvi.02792-12

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