Assignment of Sp alpha I/74 hereditary elliptocytosis to the alpha- or beta-chain of spectrin through in vitro dimer reconstitution.

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Article

Assignment of Sp alpha I/74 hereditary elliptocytosis to the alpha- or beta-chain of spectrin through in vitro dimer reconstitution.

Blood - 15 May 1990

Pothier B, Alloisio N, Maréchal J, Morlé L, Ducluzeau M T, Caldani C, Philippe N, Delaunay J

Abstract excerpt

Partial digestion of spectrin dimers in vitro has allowed the definition of domains. For example, the portions of the dimers that are involved in spectrin self-association are represented by the alpha I and the beta I domains. The alpha I domain (80 Kd) is further cleaved into a minor 78 Kd fragm...

Topics

Adolescent
Blotting, Western
Child
Chromosome Aberrations
Chromosome Deletion
Chromosome Disorders
Electrophoresis, Polyacrylamide Gel
Elliptocytosis, Hereditary
Female
Genetic Variation
Humans
Mutation
Spectrin

Source

Open in PubMed

Identifiers

PMID: 2337674

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-2337674-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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