Article
A pathogen type III effector with a novel E3 ubiquitin ligase architecture.
PLoS pathogens - 1 Jan 2013
Singer Alexander U, Schulze Sebastian, Skarina Tatiana, Xu Xiaohui, Cui Hong, Eschen-Lippold Lennart, Egler Monique, Srikumar Tharan, Raught Brian, Lee Justin, Scheel Dierk, Savchenko Alexei, Bonas Ulla
Abstract excerpt
Type III effectors are virulence factors of Gram-negative bacterial pathogens delivered directly into host cells by the type III secretion nanomachine where they manipulate host cell processes such as the innate immunity and gene expression. Here, we show that the novel type III effector XopL from the model plant pathogen Xanthomonas campestris pv. vesicatoria exhibits E3 ubiquitin ligase activity in vitro and in...
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