Article
The clinical characteristics, therapy and outcome of 85 adults with acute lymphoblastic leukemia and t(4;11)(q21;q23)/MLL-AFF1 prospectively treated in the UKALLXII/ECOG2993 trial.
Haematologica - 1 Jun 2013
Marks David I, Moorman Anthony V, Chilton Lucy, Paietta Elisabeth, Enshaie Amir, DeWald Gordon, Harrison Christine J, Fielding Adele K, Foroni Letizia, Goldstone Anthony H, Litzow Mark R, Luger Selina M, McMillan Andrew K, Racevskis Janis, Rowe Jacob M, Tallman Martin S, Wiernik Peter, Lazarus Hillard M
Abstract excerpt
The biology and outcome of adult t(4;11)(q21;q23)/MLL-AFF1 acute lymphoblastic leukemia are poorly understood. We describe the outcome and delineate prognostic factors and optimal post-remission therapy in 85 consecutive patients (median age 38 years) treated uniformly in the prospective trial UKALLXII/ECOG2993. The immunophenotype of this leukemia was pro-B (CD10(NEG)). Immaturity was further suggested by high...
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