Article
Metagenomic analyses of alcohol induced pathogenic alterations in the intestinal microbiome and the effect of Lactobacillus rhamnosus GG treatment.
PloS one - 1 Jan 2013
Bull-Otterson Lara, Feng Wenke, Kirpich Irina, Wang Yuhua, Qin Xiang, Liu Yanlong, Gobejishvili Leila, Joshi-Barve Swati, Ayvaz Tulin, Petrosino Joseph, Kong Maiying, Barker David, McClain Craig, Barve Shirish
Abstract excerpt
Enteric dysbiosis plays an essential role in the pathogenesis of alcoholic liver disease (ALD). Detailed characterization of the alterations in the gut microbiome is needed for understanding their pathogenic role in ALD and developing effective therapeutic approaches using probiotic supplementation. Mice were fed liquid Lieber-DeCarli diet without or with alcohol (5% v/v) for 6 weeks. A subset of mice were...
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