Article
Sexual reproduction and mating-type-mediated strain development in the penicillin-producing fungus Penicillium chrysogenum.
Proceedings of the National Academy of Sciences of the United States of America - 22 Jan 2013
Böhm Julia, Hoff Birgit, O'Gorman Céline M, Wolfers Simon, Klix Volker, Binger Danielle, Zadra Ivo, Kürnsteiner Hubert, Pöggeler Stefanie, Dyer Paul S, Kück Ulrich
Abstract excerpt
Penicillium chrysogenum is a filamentous fungus of major medical and historical importance, being the original and present-day industrial source of the antibiotic penicillin. The species has been considered asexual for more than 100 y, and despite concerted efforts, it has not been possible to induce sexual reproduction, which has prevented sexual crosses being used for strain improvement. However, using...
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