Article
Generation by reverse genetics of an effective, stable, live-attenuated newcastle disease virus vaccine based on a currently circulating, highly virulent Indonesian strain.
PloS one - 1 Jan 2012
Xiao Sa, Nayak Baibaswata, Samuel Arthur, Paldurai Anandan, Kanabagattebasavarajappa Mallikarjuna, Prajitno Teguh Y, Bharoto Eny E, Collins Peter L, Samal Siba K
Abstract excerpt
Newcastle disease virus (NDV) can cause severe disease in chickens. Although NDV vaccines exist, there are frequent reports of outbreaks in vaccinated chickens. During 2009-2010, despite intense vaccination, NDV caused major outbreaks among commercial poultry farms in Indonesia. These outbreaks raised concern regarding the protective immunity of current vaccines against circulating virulent strains in Indonesia....
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