Article
Homozygosity mapping of depressive disorder in a large family from Pakistan: significant linkage on chromosome 6 and 9.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 1 Mar 2013
Ayub Muhammad, Irfan Muhammad, Maclean Alan, Naeem Farooq, Blackwood Douglas
Abstract excerpt
A large family with a high prevalence of recurrent major depression and high average inbreeding coefficient was ascertained from rural Pakistan. Subjects were interviewed and diagnosed by a trained psychiatrist, 370 microsatellite markers were genotyped and the program FEstim was used for homozygosity mapping. Significant linkage was found on Chromosome 9 and Chromosome 6 after fine mapping. These regions on...
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