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Article

Vandetanib is effective in EGFR-mutant lung cancer cells with PTEN deficiency.

Experimental cell research - 15 Feb 2013

Takeda Hiromasa, Takigawa Nagio, Ohashi Kadoaki, Minami Daisuke, Kataoka Itaru, Ichihara Eiki, Ochi Nobuaki, Tanimoto Mitsune, Kiura Katsuyuki

Abstract excerpt

The effectiveness of vandetanib, an agent that targets RET, VEGFR and EGFR signaling, against EGFR-mutant lung cancer cells with PTEN loss was investigated. Two EGFR mutant non-small cell lung cancer (NSCLC) cell lines, PC-9 (PTEN wild type) and NCI-H1650 (PTEN null), were used. We transfected an intact PTEN gene into H1650 cells and knocked down PTEN expression in PC-9 cells using shRNA. The effectiveness of...

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Identifiers

PMID: 23274758
DOI: 10.1016/j.yexcr.2012.12.018

Genes

PTEN
EGFR
RET

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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