Article
The molecular nature of allelic diversity for two models of balancing selection.
Theoretical population biology - 1 Feb 1990
Gillespie J H
Abstract excerpt
This paper provides a theoretical description of the distribution of the number of mutations that separate alleles that are held in a population by balancing selection. Two models of nucleotide site epistasis are described: parity models and additive site models. Parity models are shown to result in a more uniform distribution of mutations across alleles than the neutral model, while additive sites models show a...
Topics
- Base Sequence
- DNA
- Epistasis, Genetic
- Female
- Gene Frequency
- Genetic Variation
- Genetics, Population
- Humans
- Models, Genetic
- Mutation
- Parity
- Polymorphism, Genetic