Article
The potential for isocitrate dehydrogenase mutations to produce 2-hydroxyglutarate depends on allele specificity and subcellular compartmentalization.
The Journal of biological chemistry - 8 Feb 2013
Ward Patrick S, Lu Chao, Cross Justin R, Abdel-Wahab Omar, Levine Ross L, Schwartz Gary K, Thompson Craig B
Abstract excerpt
Monoallelic point mutations in cytosolic isocitrate dehydrogenase 1 (IDH1) and its mitochondrial homolog IDH2 can lead to elevated levels of 2-hydroxyglutarate (2HG) in multiple cancers. Here we report that cellular 2HG production from cytosolic IDH1 mutation is dependent on the activity of a retained wild-type IDH1 allele. In contrast, expression of mitochondrial IDH2 mutations led to robust 2HG production in a...
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