Article
A macrocyclic calpain inhibitor slows the development of inherited cortical cataracts in a sheep model.
Investigative ophthalmology & visual science - 14 Jan 2013
Morton James D, Lee Hannah Y Y, McDermott Josh D, Robertson Lucinda J G, Bickerstaffe Roy, Jones Matthew A, Coxon James M, Abell Andrew D
Abstract excerpt
PURPOSE: We used sheep with an autosomal dominant gene for cortical cataract as an animal model to evaluate novel macrocyclic calpain inhibitors with potential for the medical treatment of human cataract. METHODS: The macrocyclic aldehyde, CAT811, identified previously as a calpain inhibitor that prevents calcium-induced opacification in cultured sheep lenses, was tested for its ability to protect cytoskeletal...
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