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Article

Autoproteolysis and intramolecular dissociation of Yersinia YscU precedes secretion of its C-terminal polypeptide YscU(CC).

PloS one - 1 Jan 2012

Frost Stefan, Ho Oanh, Login Frédéric H, Weise Christoph F, Wolf-Watz Hans, Wolf-Watz Magnus

Abstract excerpt

Type III secretion system mediated secretion and translocation of Yop-effector proteins across the eukaryotic target cell membrane by pathogenic Yersinia is highly organized and is dependent on a switching event from secretion of early structural substrates to late effector substrates (Yops). Substrate switching can be mimicked in vitro by modulating the calcium levels in the growth medium. YscU that is essential...

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Identifiers

PMID: 23185318
DOI: 10.1371/journal.pone.0049349
PMCID: PMC3504009

Genes

PTH

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Autoproteolysis and intramolecular dissociation of Yersinia YscU precedes secretion of its C-terminal polypeptide YscU(CC).PMID 23185318Read ↗

Autoproteolysis of YscU of Yersinia pseudotuberculosis is important for regulation of expression and secretion of Yop proteins.Semantic proximity Read ↗

Atomic resolution structure of the cytoplasmic domain of Yersinia pestis YscU, a regulatory switch involved in type III secretion.Semantic proximity Read ↗

A complex composed of SycN and YscB functions as a specific chaperone for YopN in Yersinia pestis.Semantic proximity Read ↗

YscB of Yersinia pestis functions as a specific chaperone for YopN.Semantic proximity Read ↗

YscU cleavage and the assembly of Yersinia type III secretion machine complexes.Semantic proximity Read ↗

Identification of SycN, YscX, and YscY, three new elements of the Yersinia yop virulon.Semantic proximity Read ↗

YscP and YscU regulate substrate specificity of the Yersinia type III secretion system.Semantic proximity Read ↗

YscP and YscU switch the substrate specificity of the Yersinia type III secretion system by regulating export of the inner rod protein YscI.Semantic proximity Read ↗

YscP of Yersinia pestis is a secreted component of the Yop secretion system.Semantic proximity Read ↗

Yersinia pestis YscG protein is a Syc-like chaperone that directly binds yscE.Semantic proximity Read ↗

YopD of Yersinia pestis plays a role in negative regulation of the low-calcium response in addition to its role in translocation of Yops.Semantic proximity Read ↗

The type III secretion chaperone LcrH co-operates with YopD to establish a negative, regulatory loop for control of Yop synthesis in Yersinia pseudotuberculosis.Semantic proximity Read ↗

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