Molecular characterization and phylogenetic analysis of the hemagglutinin 1 protein of human influenza A virus subtype H1N1 circulating in Kenya during 2007-2008.

doi:10.1093/infdis/jis586

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Article

Molecular characterization and phylogenetic analysis of the hemagglutinin 1 protein of human influenza A virus subtype H1N1 circulating in Kenya during 2007-2008.

The Journal of infectious diseases - 15 Dec 2012

Bulimo Wallace D, Achilla Rachel A, Majanja Janet, Mukunzi Silvanos, Wadegu Meshack, Osunna Finnley, Mwangi Josephat, Njiri James, Wangui Julia, Nyambura Janet, Obura Beryl, Mitei Ken, Omariba Duke, Segecha Shirley, Nderitu Martha, Odindo Alfred, Adega Charles, Kiponda Jeremiah, Mupa Ruth, Munyazi Frida, Kissinger George, Mwakuzimu Mohammed, Kamola Diana, Muhidin Elias, Kamau Daniel, Kairithia Steve, Koech Margaret, Sang Alice, Onge'ta Lynette, Schnabel David C

Abstract excerpt

BACKGROUND: Among influenza viruses, type A viruses exhibit the greatest genetic diversity, infect the widest range of host species, and cause the vast majority of cases of severe disease in humans, including cases during the great pandemics. The hemagglutinin 1 (HA1) domain of the HA protein contains the highest concentration of epitopes and, correspondingly, experiences the most intense positive selection...

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PMID: 23169971
DOI: 10.1093/infdis/jis586

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