Distinct clinical course of EGFR-mutant resected lung cancers: results of testing of 1118 surgical specimens and effects of adjuvant gefitinib and erlotinib.

doi:10.1097/JTO.0b013e31826bb7b2

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Article

Distinct clinical course of EGFR-mutant resected lung cancers: results of testing of 1118 surgical specimens and effects of adjuvant gefitinib and erlotinib.

Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer - 1 Dec 2012

D'Angelo Sandra P, Janjigian Yelena Y, Ahye Nicholas, Riely Gregory J, Chaft Jamie E, Sima Camelia S, Shen Ronglai, Zheng Junting, Dycoco Joseph, Kris Mark G, Zakowski Maureen F, Ladanyi Marc, Rusch Valerie, Azzoli Christopher G

Abstract excerpt

BACKGROUND: EGFR and KRAS mutations are mutually exclusive and predict outcomes with epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) treatment in patients with stage IV lung cancers. The clinical significance of these mutations in patients with resected stage I-III lung cancers is unclear. METHODS: At our institution, resection specimens from patients with stage I-III lung adenocarcinomas...

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PMID: 23154553
DOI: 10.1097/JTO.0b013e31826bb7b2

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EGFR
KRAS

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