Article
Exome sequencing of only seven Qataris identifies potentially deleterious variants in the Qatari population.
PloS one - 1 Jan 2012
Rodriguez-Flores Juan L, Fuller Jennifer, Hackett Neil R, Salit Jacqueline, Malek Joel A, Al-Dous Eman, Chouchane Lotfi, Zirie Mahmoud, Jayoussi Amin, Mahmoud Mai A, Crystal Ronald G, Mezey Jason G
Abstract excerpt
The Qatari population, located at the Arabian migration crossroads of African and Eurasia, is comprised of Bedouin, Persian and African genetic subgroups. By deep exome sequencing of only 7 Qataris, including individuals in each subgroup, we identified 2,750 nonsynonymous SNPs predicted to be deleterious, many of which are linked to human health, or are in genes linked to human health. Many of these SNPs were at...
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