Article
Association between CYP19A1 genotype and pubertal sagittal jaw growth.
American journal of orthodontics and dentofacial orthopedics : official publication of the American Association of Orthodontists, its constituent societies, and the American Board of Orthodontics - 1 Nov 2012
He Shushu, Hartsfield James K, Guo Yujiao, Cao Yang, Wang Si, Chen Song
Abstract excerpt
INTRODUCTION: Sagittal jaw growth is influenced during puberty by a ratio of androgens and estrogens. The CYP19A1 (formerly CYP19) gene encodes the cytochrome P450 enzyme aromatase (estrogen synthetase), which converts testosterone to estrogen. Genetic variations including single nucleotide polymorphisms might regulate CYP19A1 gene expression or the function of the aromatase protein and thus influence sagittal...
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