Article
Dengue virus therapeutic intervention strategies based on viral, vector and host factors involved in disease pathogenesis.
Pharmacology & therapeutics - 1 Feb 2013
Herrero Lara J, Zakhary Andrew, Gahan Michelle E, Nelson Michelle A, Herring Belinda L, Hapel Andrew J, Keller Paul A, Obeysekera Maheshi, Chen Weiqiang, Sheng Kuo-Ching, Taylor Adam, Wolf Stefan, Bettadapura Jayaram, Broor Shobha, Dar Lalit, Mahalingam Suresh
Abstract excerpt
Dengue virus (DV) is the most widespread arbovirus, being endemic in over 100 countries, and is estimated to cause 50 million infections annually. Viral factors, such as the genetic composition of the virus strain can play a role in determining the virus virulence and subsequent clinical disease severity. Virus vector competence plays an integral role in virus transmission and is a critical factor in determining...
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