Article
Correction of F508del-CFTR trafficking by the sponge alkaloid latonduine is modulated by interaction with PARP.
Chemistry & biology - 26 Oct 2012
Carlile Graeme W, Keyzers Robert A, Teske Katrina A, Robert Renaud, Williams David E, Linington Roger G, Gray Christopher A, Centko Ryan M, Yan Luping, Anjos Suzana M, Sampson Heidi M, Zhang Donglei, Liao Jie, Hanrahan John W, Andersen Raymond J, Thomas David Y
Abstract excerpt
Mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene cause CF. The most common mutation, F508 deletion, causes CFTR misfolding and endoplasmic reticulum retention, preventing it from trafficking to the cell surface. One approach to CF treatment is to identify compounds that correct the trafficking defect. We screened a marine extract collection and, after extract, deconvolution...
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