Article
Identification of FZD4 and LRP5 mutations in 11 of 49 families with familial exudative vitreoretinopathy.
Molecular vision - 1 Jan 2012
Yang Huiqin, Li Shiqiang, Xiao Xueshan, Wang Panfeng, Guo Xiangming, Zhang Qingjiong
Abstract excerpt
PURPOSE: To identify mutations in FZD4 and LRP5 in 49 Chinese families with familial exudative vitreoretinopathy (FEVR) and to reveal the mutation spectrum and frequency of these genes in the Chinese population. METHODS: Clinical data and genomic DNA were collected for patients from 49 families with FEVR. The coding exons and adjacent intronic regions of FZD4 and LRP5 were amplified with polymerase chain...
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