Article
Transcriptome correlation analysis identifies two unique craniosynostosis subtypes associated with IRS1 activation.
Physiological genomics - 1 Dec 2012
Stamper B D, Mecham B, Park S S, Wilkerson H, Farin F M, Beyer R P, Bammler T K, Mangravite L M, Cunningham M L
Abstract excerpt
The discovery of causal mechanisms associated with nonsyndromic craniosynostosis has proven to be a difficult task due to the complex nature of the disease. In this study, differential transcriptome correlation analysis was used to identify two molecularly distinct subtypes of nonsyndromic craniosynostosis, termed subtype A and subtype B. In addition to unique correlation structure, subtype A was also associated...
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