Article
Single-chain VEGF/Cy5.5 targeting vegf receptors to indicate atherosclerotic plaque instability.
Molecular imaging and biology - 1 Jun 2013
Lam Ming Kai, Al-Ansari Sali, van Dam Gooitzen M, Tio René A, Breek Jan-Cees, Slart Riemer H J A, Hillebrands Jan-Luuk, Zeebregts Clark J
Abstract excerpt
PURPOSE: Unstable plaques may cause clinical events. Plaque destabilization results from the synergy between intraplaque angiogenesis and inflammation. Vascular endothelial growth factor (VEGF) and VEGF receptors (VEGFRs) are considered to be involved in these processes. We investigated the efficacy of the anti-VEGFR mimic single-chain VEGF (scVEGF) to map intra-plaque VEGFR expression and atherosclerotic plaque...
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