Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Next generation sequencing methodologies--an overview.

Advances in protein chemistry and structural biology - 1 Jan 2012

Pickrell William O, Rees Mark I, Chung Seo-Kyung

Abstract excerpt

Gene discovery has been one of the most important advances in our understanding of human disorders. Early linkage and positional cloning strategies have now given way to next generation sequencing (NGS) with age-old help from biostatistical and bioinformatical input. In this chapter, we present the importance of getting the basics right, namely, how the best phenotyping in the clinical domain will provide a...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Computational Biology
Share to Phenotype
Share to Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Sequence Analysis, DNA

Source

Identifiers

PMID: 23046880
DOI: 10.1016/B978-0-12-394287-6.00001-X

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Next generation sequencing methodologies--an overview.PMID 23046880Read ↗

Next-generation sequencing technologies: breaking the sound barrier of human genetics.Semantic proximity Read ↗

The Road from Next-Generation Sequencing to Personalized MedicineSemantic proximity Read ↗

Guidelines for diagnostic next-generation sequencingSemantic proximity Read ↗

Cracking the Code of Human Diseases Using Next-Generation Sequencing: Applications, Challenges, and Perspectives.Semantic proximity Read ↗

Next-generation sequencing applied to rare diseases genomics.Semantic proximity Read ↗

Recommendations for Bioinformatics in Clinical PracticeSemantic proximity Read ↗

Next generation sequencing and the future of genetic diagnosis.Semantic proximity Read ↗

Clinical application of next-generation sequencing for Mendelian diseases.Semantic proximity Read ↗

Next-generation sequencing in the clinic: promises and challenges.Semantic proximity Read ↗

Challenges in the diagnosis and discovery of rare genetic disorders using contemporary sequencing technologiesSemantic proximity Read ↗

Next-generation sequencing: ready for the clinics?Semantic proximity Read ↗

Sequencing studies in human genetics: design and interpretation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.