Article
Substituted pyrazolones require N2 hydrogen bond donating ability to protect against cytotoxicity from protein aggregation of mutant superoxide dismutase 1.
Bioorganic & medicinal chemistry letters - 1 Nov 2012
Trippier Paul C, Benmohamed Radhia, Benmohammed Radhia, Kirsch Donald R, Silverman Richard B
Abstract excerpt
Amyotrophic lateral sclerosis (ALS) is a debilitating and fatal neurodegenerative disease. Although the cause remains unknown, misfolded protein aggregates are seen in neurons of sporadic ALS patients, and familial ALS mutations, including mutations in superoxide dismutase 1 (SOD1), produce proteins with an increased propensity to misfold and aggregate. A structure activity relationship of a lead scaffold...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.