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Article

Periodic fever, aphthous stomatitis, pharyngitis, cervical adenitis syndrome is linked to dysregulated monocyte IL-1β production.

The Journal of allergy and clinical immunology - 1 Jun 2013

Kolly Laeticia, Busso Nathalie, von Scheven-Gete Annette, Bagnoud Nathaliane, Moix Isabelle, Holzinger Dirk, Simon Gregoire, Ives Annette, Guarda Greta, So Alexander, Morris Michael A, Hofer Michaël

Abstract excerpt

BACKGROUND: The exact pathogenesis of the pediatric disorder periodic fever, aphthous stomatitis, pharyngitis, cervical adenitis (PFAPA) syndrome is unknown. OBJECTIVES: We hypothesized that PFAPA might be due to dysregulated monocyte IL-1β production linked to genetic variants in proinflammatory genes. METHODS: Fifteen patients with PFAPA syndrome were studied during and outside a febrile episode. Hematologic...

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Source

Identifiers

PMID: 23006543
DOI: 10.1016/j.jaci.2012.07.043

Genes

NLRP3
MEFV
MVK

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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