Article
Specifying and sustaining pigmentation patterns in domestic and wild cats.
Science (New York, N.Y.) - 21 Sept 2012
Kaelin Christopher B, Xu Xiao, Hong Lewis Z, David Victor A, McGowan Kelly A, Schmidt-Küntzel Anne, Roelke Melody E, Pino Javier, Pontius Joan, Cooper Gregory M, Manuel Hermogenes, Swanson William F, Marker Laurie, Harper Cindy K, van Dyk Ann, Yue Bisong, Mullikin James C, Warren Wesley C, Eizirik Eduardo, Kos Lidia, O'Brien Stephen J, Barsh Gregory S, Menotti-Raymond Marilyn
Abstract excerpt
Color markings among felid species display both a remarkable diversity and a common underlying periodicity. A similar range of patterns in domestic cats suggests a conserved mechanism whose appearance can be altered by selection. We identified the gene responsible for tabby pattern variation in domestic cats as Transmembrane aminopeptidase Q (Taqpep), which encodes a membrane-bound metalloprotease. Analyzing 31...
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