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Article

Hodgkin lymphoma requires stabilized NIK and constitutive RelB expression for survival

12 Sept 2012

Abstract excerpt

We have analyzed the role of the REL family members in Hodgkin lymphoma (HL). shRNA targeting of each REL member showed that HL was uniquely dependent on relB, in contrast to several other B-cell lymphomas. In addition, relA and c-rel shRNA expression also decreased HL cell viability. In exploring relB activation further, we found stable NF-κB inducing kinase (NIK) protein in several HL cell lines and that NIK...

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PMID: 22968463
DOI: 10.1182/blood-2012-01-405951

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