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Article

Evaluation of genes involved in limb development, angiogenesis, and coagulation as risk factors for congenital limb deficiencies.

American journal of medical genetics. Part A - 1 Oct 2012

Browne Marilyn L, Carter Tonia C, Kay Denise M, Kuehn Devon, Brody Lawrence C, Romitti Paul A, Liu Aiyi, Caggana Michele, Druschel Charlotte M, Mills James L

Abstract excerpt

We conducted a population-based case-control study of single nucleotide polymorphisms (SNPs) in selected genes to find common variants that play a role in the etiology of limb deficiencies (LDs). Included in the study were 389 infants with LDs of unknown cause and 980 unaffected controls selected from all births in New York State (NYS) for the years 1998-2005. We used cases identified from the NYS Department of...

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Topics

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Share to Blood Coagulation
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Fibroblast Growth Factor 10

Share to Infant, Newborn

Share to Limb Deformities, Congenital

Share to Morphogenesis

Share to Neovascularization, Physiologic

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Source

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Identifiers

PMID: 22965740
DOI: 10.1002/ajmg.a.35565
PMCID: PMC3448837

Genes

FGF10
CTNNB1
FGF4
FGF8
GDF5
GREM1
MTHFR
NOS3
SALL4
SHH
TBX3
TBX5
VEGFA

Provenance

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