Article
Matrix metalloproteinase (MMP)-2 and MMP-9 expression in tumor infiltrating CD3 lymphocytes from women with endometrial cancer.
International journal of gynecological cancer : official journal of the International Gynecological Cancer Society - 1 Oct 2012
Jedryka Marcin, Chrobak Agnieszka, Chelmonska-Soyta Anna, Gawron Daria, Halbersztadt Alicja, Wojnar Andrzej, Kornafel Jan
Abstract excerpt
OBJECTIVE: In this study, we hypothesized that not only endothelial malignant cells but also lymphocytes infiltrating tumor epithelium, in patients with endometrial cancer, could be an important source of the gelatinases (matrix metalloproteinase [MMP]-2 and MMP-9) extensive production, which in turn, may facilitate tumor cells infiltration and progression due to the extracellular matrix degradation. MATERIALS...
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