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Article

Chitin synthases with a myosin motor-like domain control the resistance of Aspergillus fumigatus to echinocandins.

Antimicrobial agents and chemotherapy - 1 Dec 2012

Jiménez-Ortigosa Cristina, Aimanianda Vishukumar, Muszkieta Laetitia, Mouyna Isabelle, Alsteens David, Pire Stéphane, Beau Remi, Krappmann Sven, Beauvais Anne, Dufrêne Yves F, Roncero César, Latgé Jean-Paul

Abstract excerpt

Aspergillus fumigatus has two chitin synthases (CSMA and CSMB) with a myosin motor-like domain (MMD) arranged in a head-to-head configuration. To understand the function of these chitin synthases, single and double csm mutant strains were constructed and analyzed. Although there was a slight reduction in mycelial growth of the mutants, the total chitin synthase activity and the cell wall chitin content were...

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Identifiers

PMID: 22964252
DOI: 10.1128/AAC.00752-12
PMCID: PMC3497188

Genes

MMD

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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Chitin synthases with a myosin motor-like domain control the resistance of Aspergillus fumigatus to echinocandins.PMID 22964252Read ↗

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