A high-coverage genome sequence from an archaic Denisovan individual.

doi:10.1126/science.1224344

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Article

A high-coverage genome sequence from an archaic Denisovan individual.

Science (New York, N.Y.) - 12 Oct 2012

Meyer Matthias, Kircher Martin, Gansauge Marie-Theres, Li Heng, Racimo Fernando, Mallick Swapan, Schraiber Joshua G, Jay Flora, Prüfer Kay, de Filippo Cesare, Sudmant Peter H, Alkan Can, Fu Qiaomei, Do Ron, Rohland Nadin, Tandon Arti, Siebauer Michael, Green Richard E, Bryc Katarzyna, Briggs Adrian W, Stenzel Udo, Dabney Jesse, Shendure Jay, Kitzman Jacob, Hammer Michael F, Shunkov Michael V, Derevianko Anatoli P, Patterson Nick, Andrés Aida M, Eichler Evan E, Slatkin Montgomery, Reich David, Kelso Janet, Pääbo Svante

Abstract excerpt

We present a DNA library preparation method that has allowed us to reconstruct a high-coverage (30×) genome sequence of a Denisovan, an extinct relative of Neandertals. The quality of this genome allows a direct estimation of Denisovan heterozygosity indicating that genetic diversity in these arc...

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PMID: 22936568
DOI: 10.1126/science.1224344
PMCID: PMC3617501

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22936568-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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