Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Down's syndrome and Alzheimer's disease: towards secondary prevention.

Nature reviews. Drug discovery - 1 Sept 2012

Ness Seth, Rafii Michael, Aisen Paul, Krams Michael, Silverman Wayne, Manji Husseini

Abstract excerpt

A public-private partnership to establish biomarkers of dementia in Down's syndrome could aid the development of preventive therapies for the dementia associated with both Down's syndrome and Alzheimer's disease, based on the apparent common pathogenic role of amyloid precursor protein in the two conditions.

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alzheimer Disease
Share to Amyloid beta-Peptides
Share to Apolipoprotein E4

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Down Syndrome

Share to Genetic Markers

Share to Genotype

Share to Secondary Prevention

Source

Identifiers

PMID: 22935789
DOI: 10.1038/nrd3822

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Down's syndrome and Alzheimer's disease: towards secondary prevention.PMID 22935789Read ↗

Alzheimer's disease in Down syndrome: An overlooked population for prevention trialsSemantic proximity Read ↗

From understanding to action: Exploring molecular connections of Down syndrome to Alzheimer's disease for targeted therapeutic approachSemantic proximity Read ↗

Alzheimer’s disease in people with Down’s syndrome: the prospects for and the challenges of developing preventative treatmentsSemantic proximity Read ↗

Dementia in Down syndrome: unique insights for Alzheimer disease researchSemantic proximity Read ↗

Alzheimer’s Disease in Down Syndrome: Progress in the Design and Conduct of Drug Prevention TrialsSemantic proximity Read ↗

Aging with Down Syndrome—Where Are We Now and Where Are We Going?Semantic proximity Read ↗

Genetics of Down's syndrome and Alzheimer's diseaseSemantic proximity Read ↗

A genetic cause of Alzheimer disease: mechanistic insights from Down syndrome.Semantic proximity Read ↗

The Down Alzheimer Barcelona Neuroimaging Initiative (DABNI) and its contributions to understanding Alzheimer's disease in Down syndrome: A decade of discoverySemantic proximity Read ↗

Comparison of CSF biomarkers in Down syndrome and autosomal dominant Alzheimer's disease: a cross-sectional study.Semantic proximity Read ↗

The Alzheimer's Biomarker Consortium‐Down Syndrome: Rationale and methodologySemantic proximity Read ↗

Down syndrome, Alzheimer disease, and cerebral amyloid angiopathy: The complex triangle of brain amyloidosisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.